贝伐珠单抗在结直肠癌中的耐药机制及串珠素干预治疗的研究-肿瘤学专业论文.docxVIP

解放军医学院硕士学位论文 解放军医学院硕士学位论文 万方数据 万方数据 The research of bevacizumab drug-resistance and perlecan intervention in colorectal carcinoma Abstract Objective To explore the mechanism of bevacizuamb drug-resistance in vitro and detect the change of vascular endothelia growth factors and perlecan in colorectal carcinoma cells and conditioned medium. At the same time to detect the effect of perlecan intervention on the proliferation of carcinoma cells and to evaluate the influence of perlecan intervention on bevacizuamb drug resistance. Methods The proliferation of carcinoma cells was detected by MTS arra