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® 50 044136 ® Pletaal tablets 50 G-7348 ® 100 044124 ® Pletaal tablets 100 G-7349 Pletaal Cilostazol quinolinone phosphodiesterase phosphodiesterase III 狀 1.狀 cilostazol 列 carboxymethylcellulose calcium, corn starch, hydroxypropyl 率 methylcellulose 2910, magnesium stearate, microcrystalline cellulose Cilostazol 率95-98% Pletaal 50 1 cilostazol 50 mg OG31 率3,4-dehydro-cilostazol 97.4% 4-trans-hydroxy-cilostazol 66% Pletaal 100 1 cilostazol 100 mg OG30 度不離Cilostazol 2.理 27% Cilostazol Erythromycin Cilostazol Quinidine Warfarin Omeprazole 不臨 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2 (1H)-quinolinone C H N O Cilostazol 尿 20 27 5 2 量 369.46 Cilostazol CYP3A4 CYP2C19 狀Cilostazol ~methanol ethanol 3,4-dehydro-cilostazol 不0.1 N HCl 0.1N NaOH Cilostazol 100 mg 56%Cilostazol 15%3,4-dehydro-cilostazol Cilostazol 4-7 4%4-trans-hydroxy-cilostazolCilostazol 1/5 Cilostazol 尿74% 便 20% 尿 不Cilostazol 不量2%3,4-dehydro- cilostazol 30%4-trans-hydroxy-cilostazol 尿 5% Cilostazol 臨理 1. Pletaal 行療Pletaal 1)年 數cyclic AMP cAMP phosphodiesterase III PDE III Cilostazol 廓率廓率 phosphodiesterase cAMP 50-80 年年異 cAMP 度