15其他白细胞检验（2）.pptVIP

t(11;14)(q13;q32) in Multiple Myeloma Breakpoints spread over ~300kb Associated with ectopic expression of cyclin D1 at 11q13 t(4;14)(p16;q32) in multiple myeloma occurs in ~20% of myeloma breakpoints spread over 150kb associated with ectopic expression of FGFR3 on der(4) and IgH-MMSET hybrid mRNA transcripts on der(14) Chromosome 14 paint in orange 4p16.3 cosmid in green 6.细胞遗传学与分子生物学 采用PCR技术检测免疫球蛋白重链基因IgH异位可能是MM发病早期遗传学改变，且于疾病进展有关。 7. MM的诊断 MM诊断标准(WHO Criteria After 2008): 克隆性浆细胞增生造成器官与组织损伤 高血钙(hypercalcemia) 肾功能不全(renal insufficiency) 贫血(anemia) 骨质破坏(bone lesions) 其他：感染、淀粉样病变等 M