中药促进脑缺血血管生成研究进展-中国中医药信息杂志.PDF

2018 年7月第 25卷第7期 中国中医药信息杂志 ·137 · 中药促进脑缺血血管生成研究进展 1，2 3 3 黄生辉 ，李妍怡 ，巩婷 1.甘肃中医药大学中西医结合学院，甘肃 兰州 730000 ；2.甘肃中医药大学附属医院神经内科，甘肃 兰州 730000 ； 3.甘肃省中医院脑病科，甘肃 兰州 730050 摘要：单味药及其有效成分、中药复方及中成药对血管的促进、抑制作用为目前研究热点，但中药对脑缺 血后促进血管生成的作用及机制相关研究尚未深入。本文对中药促进脑血管生成的中医理论、体外研究、在体 研究进行综述，并对通过 Notch 和 Wnt 信号通路调控血管生成的机制研究进行重点阐述，为药理作用机制研 究及新药研发提供参考。 关键词：中药；脑缺血；血管生成；血管内皮生长因子；Notch 信号通路；Wnt 信号通路；综述 DOI：10.3969/j.issn.1005-5304.2018.07.036 中图分类号：R277.73 文献标识码：A 文章编号：1005-5304(2018)07-0137-04 Research Progress in TCM Promoting the Development of Cerebral Ischemia Angiogenesis 1,2 3 3 HUANG Sheng-hui , LI Yan-yi , GONG Ting 1. Cooperation of Chinese and Western Medicine College, Gansu University of Chinese Medicine, Lanzhou 730000, China；2. Department of Neurology, Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730000, China；3. Department of Encephalopathy, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China Abstract: The promotion or inhibition of blood vessels by TCM, active ingredients of TCM, TCM compounds, and Chinese patent drugs is currently a research hotspot, with relatively abundant research. However, the study of the role and profound mechanism of TCM on angiogenesis after cerebral ischemia is relatively rare. Therefore, this article reviewed theories, in vitro studies and in vivo studies on the promotion of cerebral angiogenesis by TCM, and summarized the studies on TCM regulation of angiogenesis through Notch and Wnt signaling pathway mechanisms, with a pu