高耐药性肺癌患者PICC相关性深静脉血栓形成的-中国医学前沿杂志.PDF

128 ● ● 《中国医学前沿杂志 （电子版）》2017 年第9 卷第10 期  论著  DOI ：10.12037/YXQY.2017.10-27 高耐药性肺癌患者PICC 相关性深静脉 血栓形成的相关影响因素分析 顾静芝，刘静 （上海市肺科医院　门诊，上海　200433 ） 【摘要】目的 分析高耐药性肺癌患者外周静脉置入中心静脉导管 （peripherally inserted central cath- eter ，PICC ）相关性深静脉血栓形成的危险因素。方法　回顾性分析2015 年5 月至2017 年5 月本院收 治的156 例行PICC 化疗的高耐药性肺癌患者的临床资料，分析高耐药性肺癌患者PICC 置管后深静脉 血栓形成的危险因素。结果　156 例高耐药性肺癌患者中，发生PICC 相关性深静脉血栓18 例，发生 率为11.54% 。多因素Logistic 回归分析显示：女性、头静脉置管、PICC 留管时间＞1 个月、纤维蛋 白原水平＞4 g/L 、D- 二聚体水平＞0.5 mg/ml 及腺癌是高耐药性肺癌患者PICC 相关性深静脉血栓形 P 成的独立危险因素 （ ＜0.05 ）。结论　性别、穿刺静脉、纤维蛋白原、D- 二聚体、留管时间以及病 理类型为高耐药性肺癌患者PICC 相关性深静脉血栓形成的危险因素，临床需予以重点关注和及早预 防，以降低PICC 相关性深静脉血栓形成的发生风险。 【关键词】高耐药性肺癌 ；深静脉血栓；外周静脉置入中心静脉导管；危险因素 Analysis of the influencing factors of PICC associated deep vein thrombosis in patients with high drug resistance to lung cancer GU Jing-zhi, LIU Jing (Clinic, Shanghai Pulmonary Hospital, Shanghai 200433, China) Corresponding author: GU Jing-zhi, E-mail: shgj z052 1@163.com Abstract Objective 【 】 　To analyze the influencing factors of peripherally inserted central catheter (PICC) related deep vein thrombosis in patients with high drug resistance to lung cancer. Method　The clinical data of 156 patients with drug resistance to lung cancer treated with PICC chemotherapy in our hospital from May 20 15 to May 20 17 were retrospectively analyzed. Analyzed the influencing factors of PICC related deep vein thrombosis in patients with high drug resistance to lung cancer. Result　Of 156 patients with high drug resistance to lung cancer, 18 cases of PICC related deep venous thrombosis were found, the incidence was 11.54%. Multivariate Logistic regression analysis showed that the female, head vein catheterization, retention time ＞1 month, fibrinogen level ＞4 g/L, D-dimer level ＞0.5 mg/ml and adenocarcinoma were the independent risk factors of PICC associated deep vein thrombosis in patients with high drug res