卵巢癌患者手术治疗前后血清IGFI、A125、ys水平的变化及临床意义.docVIP

卵巢癌患者手术治疗前后血清IGF-I、CA125、CysC水平的变化及临床意义 王国华1 金钧2 (1连云港市第一人民医院妇产科 222002; 2连云港市第一人民医院检验科 222002) 】目的探讨卵巢癌患者手术治疗前后血清IGF-I、CA125和CysC水平的 变化及临床意义。方法应用放射免疫分析法和胶乳增强免疫比浊法对33例卵 巢癌患者进行了手术治疗前后血淸IGF-I、CA125和CysC水平检测，并与35名正 常健康人作比较。结果卵巢癌患者在手术治疗前IGF-I、CA125和CysC水平均 非常显著的高于正常人组(Plt;0.05),手术治疗3个月后则与正常人比较无显 著性差异(Pgt;0.05),血淸IGF-I水平与CA125、CysC水平呈正相关(r= 0.6138,.5019.P0.01)。结论卵巢癌患者3项指标测定对卵巢癌的诊断、疗效 观察和预后评估有帮助。 关键词】卵巢癌胰岛素样生长因子-I糖类抗原-125 胱抑素C 】R730.5 】A 】2095-1752 (2013) 27-0116-02 Clinical Significancen of Measurement the Changes of Serum IGF-I,A125 and CysC Levels After Operation in Patients wth Ovarian Cancer WANG Guo-hual,JIN Jun2 (1.Department of Obsterics and Gynecology;2.Department of Clinical Laboratory,The First Peoplersquo;s Hospital of Lianyungang,Lianyungang 222000,China) [Abstract] Objective:To explore the clinical significance of changes of serum IGF-I,CA125 and CysC levels after operation in patients with ovarian cancer.Methods: Serum IGF-I,CA125 (with RIA) serum CysC (with latex ndash;enhanced immunoturbidimetryassay) levels were determined in 33 patients with ovarian cancer and 35 controls.Results: Before operation,serum IGF-I,CA125 and CysC levels were significantly higher than those in controls (Plt;0.01).After operation for 3 months,the levels were not significantly different from those in controls (Pgt;0.05).Serum IGF-I levels were positively correlated with serum CA125,CysC levels (r=0.6138,0.5019. Plt;0.01).Conclusions:Detection of changes of serum IGF-I,CA125 and CysC levels in patients with ovarian cancer was helpful for diagnosis and outcome prediction. Key Words] varian cancer insulin-like growth factor-1 (IGF-I) carbohydrate antigen 125 (CA125) Cystatin C (CysC) 卵巢癌为妇产科的恶性肿瘤，其发病机理颇受临床和科研工 的关注 [1】。为了进一步了解卵巢癌的发生与发展，我们对33例均临床明确的卵巢癌患 者进行手术治疗前后血清IGF-I、CA125和CysC水平的检测，旨在探讨其在临床 上的价值。现将我们的结果报告如下： 1资料与方法 1.1临床一般资料 1.1.1病人组：33人，均为我院经临床明确诊断的卵巢癌患者，所奋病 人均经肿瘤相关指标的测定、B超、X线摄片、CT,部分病人经MRI证实，最后 经手术后病理切片证实。 1.1.2正常人组：35人，均为我院体检中心经健康体检合格的正常人, 无心、肝、肺、肾等重要脏器疾患，肝、肾功能试验正常，