简易精神状态量表评分正常慢性阻塞性肺疾病患者脑认知功能的研究.docVIP

简易精神状态量表评分正常慢性阻塞性肺疾病患者脑认知功能的研究 　　[摘要]目的 探讨简易精神状态量表（MMSE）得分正常的慢性阻塞性肺疾病（COPD）患者是否存在脑认知功能障碍。方法 选择2012年7月～2015年3月在我院就诊的60例MMSE评分正常的稳定期COPD患者和60例正常对照组。利用蒙特利尔认知评估量表（MoCA）对两组受试者进行评分，分别对其MoCA总分和视空间执行力、命名能力、注意力、语言流畅、抽象思维、延迟回忆和空间定向能力等子项分析比较。结果 COPD组与正常对照组MMSE总评分、MoCA总评分比较，差异有统计学意义（P0.05）。MoCA子项中COPD组较正常对照组的视空间执行能力（P=0.028）、命名能力（P=0.024）及延迟回忆（P0.001）有明显下降；而注意力、语言流畅、抽象思维、空间定向比较，差异无统计学意义。结论 MMSE正常的COPD患者仍然存在脑认知功能障碍，MoCA筛查COPD患者脑认知障碍能力优于MMSE。 　　[关键词]慢性阻塞性肺疾病；简易精神状态量表；蒙特利尔认知评估量表；脑认知障碍 　　[中图分类号] R563 [文献标识码] A [文章编号] 1674-4721（2016）07（a）-0036-03 　　[Abstract]Objective To investigate whether there is brain cognitive impairment in patients with chronic obstructive pulmonary disease（COPD） whose mini-mental state examination（MMSE） score are normal.Methods Sixty patients with stable COPD whose MMSE score were normal in our hospital and sixty normal controls from the local community from July 2012 to March 2015 were recruited.All subjects were assessed with the montreal cognitive assessment scale（MoCA） including visuospatial and executive function，naming ability，attention，language fluency，abstraction，memory and orientation.The differences of the MoCA scores were analyzed and compared respectively between two groups.Results The MMSE total score，MoCA total score of COPD patients was lower that in normal controls respectively with statistical difference（P0.05）.Visuospatial and executive function（P=0.028），naming ability（P=0.024） and memory（P0.001） were significantly worse in COPD than normal controls，but there were no significant differences in attention， language fluency，abstraction，orientation.Conclusion There is still brain cognitive impairment of the patients with COPD whose MMSE score are normal.It is better to use MoCA than MMSE screening COPD patients in cognitive impairment. 　　[Key words]Chronic obstructive pulmonary disease（COPD）；Mini-mental state examination（MMSE）；Montreal cognitive assessment scale（MoCA）；Brain cognitive impairment 　　慢性阻塞性肺疾病（chronic obstructive pulmonary dis