《生理学》CHAPTER II ENDOCRINE SYSTEM-2培训资料.pptVIP

Section 3 Thyroid Gland;Thyroid Hormones( TH);Synthesis and secretion of thyroid hormones ;Synthesis and secretion of TH include 4 stages;transport of iodine including 2 steps ;Na+-I- pump requires energy provided by Na+-K+-ATPase ATP →Na+-K+-ATPase activity↑→ extracellular Na+↑ →Na+ diffuse inside↑ →Iˉ transported by Na+-Iˉ pump↑ (I iodine: 2 Na+-contransport,协同转运);(2) Iodide oxidation and iodination tyrosine;②The oxidized iodine binds with tyrosine residues(残基) of TG. This process is called iodination of tyrosis Tyrosine is first iodized to form monoiodotyrosine(MIT，一碘甲腺原氨酸)，then to diiodoty