第13章-细胞周期与细胞（翟中和第四版）.pptVIP

Polo-like kinase-1 (PLK1) is an essential mitotic kinase regulating multiple aspects of the cell division process. Here, activation of PLK1 is shown to occur before mitosis and to depend on phosphorylation by aurora-A kinase, facilitated by a cofactor Bora. The initial activation of PLK1 seems to be a primary function of aurora-A. * /cell/jsfl.htm * 中期II的阻滞被认为是蛋白激酶Mos引起的，Mos抑制细胞周期蛋白 B的降解。 只要细胞周期蛋白B维持在较高水平，卵母细胞中Cdk的活性保持稳定，细胞不能进入下一个减数分裂周期。 中期II停滞只有在卵受精后才能解除.受精导致Mos的降解及随后Cdk的失活 * /nature/journal/v461/n7261/images/461177a-f1.2.jpg The bird Z chromosome, but not the W, carries DMRT1, the