医学常见的水凝胶.pptVIP

高分子凝胶的体积相转变 　按高分子凝胶的响应性分类 pH- sensitive hydrogels 含有羟基或胺基 Most common ionic polymers: poly(acrylamide) PAAm, poly(acrylic acid)聚丙烯酸 (PAA), poly(methacrylic acid) (PMAA)聚甲基丙烯酸 , poly(diethylaminoethyl methacrylate)二乙基胺基乙基甲基丙烯酸酯 (PDEAEMA), and poly(dimethylaminoethyl methacrylate) (PDMAEMA) In acid medium, the gel did not swell significantly; in neutral or basic media, the gels swelled to a high degree because of ionization of the pendant acid group Temperature-sensitive hydrogels poly(N-isopropylacrylamide) and its copolymers nylon capsule grafted poly(IPAAm) Temperature-sensitive hydrogels Poly(N-isopropyl acrylamide)聚异丙基丙烯酰胺 (PNIPAAm) LCST (lowest critical solution temp): 34.30C Below LCST: significant gel swelling occurred, Transition about this point as reversible LCST raised when PNIPAAm copolymer with small amount of ionic monomers Heterogeneous gels containing PNIAAm collapsed at significantly faster rate than homopolymer of PNIPAAm Temperature-sensitive hydrogels Comb-type graft hydrogels of PNIPAAm: main chain of the cross-linked PNIPAAm contain small-molecular-weight graft of PNIPAAm Under condition of gel collapse (above LCST), hydrophobic regions were developed in the pores of the gel resulting in a rapid collapse The materials had the ability to collapse from a fully swollen conformation in less than 20 minutes Gel without graft chain required up to a month to fully collapse Major promise for rapid and abrupt or oscillatory release of drugs, peptides, or proteins Applications of Hydrogels in Drug Delivery Applications of Hydrogels in Drug Delivery Applications of Hydrogels in Drug Delivery Applications of Hydrogels in Drug Delivery Applications of Hydrogels in Drug Delivery Applications of Hydrogels in Drug Delivery (4) Glucose sensitive hydrogel Poly(N-vinylpyrrolidone-co-pHenyl voronic acid) Poly(NVP-co-PBA)) Specific molecule-sensitive hydrogel : glucose-sensitive hydrogel Insulin reservoir G G G G G G G G G G I I I I I I I I I I I I + G G