A review of analytical methods for the determination英文版本.pdfVIP

Anal Bioanal Chem (2010) 397:1191– 1201 DOI 10.1007/s00216-010-3633-8 REVIEW A review of analytical methods for the determination of 5-fluorouracil in biological matrices Massimo Breda Simona Barattè Received: 25 May 2009 /Revised: 24 February 2010 /Accepted: 3 March 2010 /Published online: 11 April 2010 # Springer-Verlag 2010 Abstract 5-Fluorouracil (5-FU) is a cytostatic agent that the past 20 years 5-FU has been useful as a cytostatic agent has been widely used in the treatment of various solid in the treatment of solid tumours, includ