壮骨胶囊防治类固醇大鼠肾阳虚的试验研究-中国骨质疏松杂志.PDF

76 CHINESET0URNALOFOSTEOPOROSISVo[．5No．41999 药物研究 壮骨胶囊防治类固醇大鼠肾阳虚的实验研究 吴铁 幸青南 胡#j 幸朝阳 黄连芳 崔燎 摘要 用泼尼抡建立类固醇性太鼠骨质疏松模型并探讨壮骨胶囊对类固醇性骨质疏松模型的预防 作用 方法 取酷酸泼尼桧按4．5mg／kg灌胃，每周2次，共9o天，同时设立对照组和壮骨胶囊和康力龙 防治组 实验结束后取太鼠胫骨近端作骨组织形态计量学观察，井取血液作各项生化指标检查 结果 壮骨胶囊组对类固醇所致的大鼠骨量减少有明显的抵抗作用，还有明显的降血脂作用；研究还观察到壮 骨胶囊有血钙下降及血锌明显增高表现。结论 壮骨胶囊对泼尼松所致的类固醇性骨质疏松有预防作 用并有明显的降血脂作用。 关键词 壮骨胶囊 泼尼松 康力龙 骨质疏橙 血锌 ExperimentalstudyollZhuanggucapsuleinpreventingprednisoneinducedoeteoporo~isofrats WuTie，LiQ[ngnan，HuBin，etal BoneBiologyLaboratoryG·uangdongMedicalCollege，Zha~ian524023，China Abstract 0bjectlve TostudytheeffectivenessofZhuanggucapsuleinpreventingglucocort[eoid— inducedosteoporosisofrats．Method Thirty—twomaleSprague—Dawleyratsat3monthsofagewere dividedrandomlyinto4groups．P~ednisoneacetatewasgiventogroupBtwiceperweek，Zhuanggucap— suleaddedtoprednisonewasgiventogroupC，whilegroupA wasusedascontro1．Thehistomor— phometricparametersofhoneslidesofprox[maltibiaweremeasuredandcalculatedwithimage pattern analyserafter3monthsofmedication．Bloodsampleswereexaminedforhiochem[caIindicesoffunction ofliveraM kidneywithCL一7200automatism biochemicalanalyzer．Result ComparedwithgroupA，in groupB theareaandnumberoftrabeculadecreasedttheintertrabecularspaceincreasedowingtothe boneresorptionsurpassingtheboneformation，andobvioussymptomsof osteoporosiswererevealed． However·ingroupC，theboneresorptionratewasma rkedlyinhibitde ，andtheformationofnew hone acceleratedsothatthebonenlassnicreasedsignificantly．Nosignificantdifferencesinbiochemicalindices offunctionofliverandkidneybetweenprednisoneandZhuangng capsuletreatedgroups．Conclusion Zhuanggucapsu~canpreventtheOsteoporos[sinducedbyprednisoneacetate． Keywords Zhuanggucapsule Prednisoneacetate Stan