生物化IILectureAminoacidcatabolism.pptVIP

Overview Amino acid oxidation Transamination and deamination Role of pyridoxal phosphate (PRPP) Urea cycle NH3 transport in body (gln, ala) NH3 ? urea Amino acid degradation – fate of carbon skeleton Example A: Thr, gly, ser, ala (tetrahydrofolate rxn) Example B: Phe, Tyr Example C: Val Diseases and disorders (some examples) Amino acid metabolism Amino acids are not stored like glucose or fatty acids Ie: no polymeric form dedicated for “reserves” of amino acids Only muscle provides any real source if not supplemented in diet Humans lost ability to synthesize 10 amino acids Most of them requir