碘催化的葡萄糖异亚丙基缩酮反应研究.PDF

※工艺技术 食品科学 2009, Vol. 30, No. 14 153 韩兴谦，何计国* ，陈尚武，李 博 ( 中国农业大学食品科学与营养工程学院，北京 100083) 以无水葡萄糖为原料、碘为催化剂，催化无水葡萄糖与丙酮的异亚丙基缩酮反应，形成1,2-5,6- 双- 氧- 异丙叉- α-D- 呋喃葡萄糖(1,2-5,6-di-O-isopropylidene- α-D-glucofuranose ，diacetone glucose ，DAG) ，并对反应条 件进行初步研究。结果表明：碘做催化剂，在回流条件下，5h 能催化葡萄糖与丙酮生成产物DAG ；而在低于 回流温度反应时，反应时间明显变长。在反应物料最佳物质的量比为葡萄糖:碘:丙酮=1:0.15:122.5 时，最高收率为 75% 左右；4A 分子筛的加入并不能显著提高反应收率。 碘；1,2-5,6- 双- 氧- 异丙叉- α-D - 呋喃葡萄糖；丙酮；缩合反应 Iodine-Catalyzed Reaction of D-Glucose with Aceton for the Preparation of 1,2-5,6-di-O-Isopropylidene-alpha -D- glucofuranose (DAG) HAN Xing-qian ，HE Ji-guo* ，CHEN Shang-wu ，LI Bo (College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China) Abstract ：1,2-5,6-di-O-Isopropylidene-a-D-glucofuranose (DAG), a glucose derivative, was obtained by the reaction of D- glucose with acetone. Effects of various conditions such as temperature, D-glucose/iodine/acetone ratio (molar) and amount of added 4A molecular sieve on production yield of DAG were investigated. In the presence of iodine, heating for 5 h under reflux (at 62 ℃) allowed the generation of DAG from the reaction between D-glucose and acetone. However, the reaction time was greatly extended when the reaction temperature was below 62 ℃. At optimized D-glucose/iodine/acetone ratio of 1:0.15:122.5, the yield of DAG was found to be close to 75%. No obvious effect was found on the yield of DAG with the addition of 4A molecular sieve. Key words ：iodine ；1,2-5,6-di-O-isopropylidene-a-D -glucofuranose ；acetone ；condensation 中图分类号：TQ203.2 文献标识码：A 文章编号：1002-6630(2009)14-0153-03 1,2-5,6- 双- 氧- 异丙叉- α-D- 呋喃葡萄糖(1,2-5,6-di- 低；然而国外开发的一些新型催化剂、价格昂贵、不 O -isopropy