Syndecan-1分子表达水平与子宫内膜增生症进展及预后的关系.docVIP

Syndecan-1分子表达水平与子宫内膜增生症进展及预后的关系 ? 24?国压塞眉医堂旦筮卷第9期ChinaClinPracMed. Sep2010,Vo1.4.No.9 Syndecan一1分子表达水平与子宫内膜增生症 进展及预后的关系 谭益军高伟飞 【摘要】目的探讨Syndecan-1分子表达水平与子宫内膜增生症进展与预后的关系.方法采用 免疫组织化学染色技术,检测15例单纯性子宫内膜增生(SH),15例复杂性子官内膜增生(CH),15例非 典型增生(AH),24例子宫内膜癌(EC)组织中Syndecan-1分子的表达,与8例正常子宫内膜(NE)组织 中的Syndecan一1表达水平进行比较分析.结果Syndecan.1在NE,SH,CH,AH,EC中的表达平均分值 分别为0.50,0.53,1.27,1.67,1.88.Syndecan一1在CH和AH中的表达显着高于SH(Plt;0.001),CH, AH,EC中Syndeean一1的表达明显强于NE(P=0.041,P=0.006,P=0.02),而NE中Syndecan-1的表达 与SH的比较无差异(Pgt;0.50).结论Syndecan-1分子表达增高可能促进子宫内膜的恶性转化,检测 Syndecan.1分子表达水平可帮助评估子宫内膜增生症预后. 【关键词】Syndecan-1;子宫内膜增生症;表达;预后 RelationshipsBetweenTheExpressionofSyndecan-1andEndometrialHyperplasiaProgressionand PrognosisTANYi-jun,GAOWei-fei.DepartmentofObstetricsandGynaecologyofLoudiCityTraditionalChi— neseMedicalHospital,LoudiHunan,Loudi417000,China 【Abstract】ObjectiveToexploretherelationshipsbetweentheexpressionofsyndeean-1andendome— trialhyperplasiaprogressionandprognosis.MethodsWithimmunohistochemicalstainingofsyndecan?1,we analyzedspecimensfrompatientswithnormalendometrium(NE,N=8)ascontrols,andthoseofsimplehyper- plasia(SH,N=15),complexhyperplasiawithoutatypia(CH,N=15),atypicalhyperplasia(AH,N=15), andendometrialcancer(EC,N=24).ResultsThemeanscoresofexpressionbasedonthe~equencyofsyn- decan-1stainingwere0.50,0.53,1.27,1.67and1.88forNE,SH,CH,AHandEC,respectively(Plt; 0.001).Syndeean一1expressionwassignificantlygreaterinCH(Plt;0.001)orAH(Plt;0.001)thaninSH. Syndecan一1ismore~equendyexpressedinCH(P=0.041),AH(P=0.006),orEC(P=0.02)thaninNE. Syndecan-1expressiondidnotdiffersignificantlybetweenNEandSH(Pgt;0.50).ConclusionUp—regulated expressionofsyndecan?-1maypromotemalignanttransformationoftheendometriumandtheimmunohistoehemi?? calstudyofsyndecan-1expressionmakeforevaluationofprognosisofendometrialhyperplasia. 【Keywords】Syndecan一1;Endometrialhyperplasia;Expression;Prognosis 子宫内膜癌(endometrialcancer,EC)是女性生殖道最常 见的肿瘤之一,其发病率和死亡率有逐年上升的趋势.近年 研究表明…,Syndecan一1作为肿瘤微环境的重要调节者,在 肿瘤细胞分化,增殖,侵袭转移,血管生成等过程中起重要作 用.但Syndeean一1