细胞周与及细胞凋亡.pptVIP

Apoptosis Necrosis 凋亡细胞的生物学特征及鉴别 死亡受体（death receptors） 位于细胞膜，能与相应配体特异性结合并通过一系列基因调控启动细胞凋亡程序最终导致细胞死亡的受体。研究较多的有Fas（CD95，APO-1），TNFR, DR3, DR4 and DR5等。 Death Domain-细胞凋亡 Fas–associated protein with death domain TNF receptor-1–associated death domain protein Apoptosis Apoptosis, or programmed cell death, is a regulated physiological process leading to cell death characterized by cell shrinkage, membrane blebbing and DNA fragmentation. Caspases, a family of cysteine proteases, are central regulators of apoptosis. Initiator caspases (including 8, 9, 10 and 12) are closely coupled to pro-a