老年痴呆实验动物模型门都研制进展.pptVIP

老年痴呆实验动物模型研制进展 Research Progress of Animal Models for Alzheimer’s Disease 张 斌 (Bin Zhang) M.D., Ph.D. 老年痴呆神经病理Neuropathology of AD 理想的老年痴呆实验动物模型标志 Idea AD Animal Models 老年痴呆实验动物模型种类Types of AD Animal Models 老年痴呆实验动物模型种类(续)Types of AD Animal Models 老年痴呆实验动物模型种类(续)Types of AD Animal Models Tau基因的变异Mutations in the Tau Gene 正常 Tau蛋白的功能Normal Tau Protein 正常Tau旦白的功能: 稳定微管并维持正常的神经元轴突转运Normal Tau Stabilizes MTs To Maintain Neuronal Transport  RW Tau 蛋白的分布改变: 从轴突到细胞体 RW Tau 蛋白的分布改变: 从轴突到细胞体Absence of Tau Staining in the Massy Fibers of Hippocampus in RW Mice 微管稳定药物MT Stabilizing Drugs