nsaid没相关性胃粘膜损伤的防治.pptVIP

NSAID相关性胃肠粘膜损伤的防治 刘玉兰 北京大学人民医院消化科 NSAIDsNon-steroidal anti-inflammatory drugs 目前NSAIDs广泛用于临床所涉及的学科: NSAIDs广泛用于临床但副作用大大限制了其使用  主要副作用?糜烂性食道炎?糜烂性胃炎:半数内镜下 ?消化性溃疡:10-25% ?上消化道出血:1-2% NSAID users are at risk of reflux esophagitis Reflux esophagitis: the presence of definite mucosal breaks or metaplasia of the esophagus, visible under endoscopy. Among patients taking non-selective NSAIDs for osteoarthritis, the prevalence rate of erosive esophagitis was 21%. NSAID-associated peptic ulceration The majority of patients develop some gastric erosions after each dose