3solubi喂lity.pptVIP

Physicochemical properties: structure; melting point; boiling point; solubility; dissolution rate; crystal properties and polymorphism; pKa; partition coefficient; stability Properties related with dosage forms: hygroscopic; micromeritics (particle size, shape, and surface area, density, flowability; porosity); interaction; Biological properties: membrane permeability; pharmacokinetics parameters Formulation challenges with poor soluble compound Factors causing poor solubility Solubility criteria (1) Dependent on the dose and permeability Biopharmaceutics Classification Syst