联合检测nf-kbp50门、nf-kbp65在甲状腺癌中的表达及意义修改版20141012.docVIP

NF-kBP50、NF-kBP65在甲状腺癌中的表达及意义 [摘要]: 目的 方法 结果 结论 [关键词]：[Abstract]: Objective Discussion NF-KBp50, NF-kBp65 protein in thyroid cancer, thyroid adenoma, nodular goiter and normal thyroid tissues and their correlation with thyroid cancer invasion and metastasis. Methods Immunohistochemical staining was used to detect the expression of p50 NF-kB and NF-kB p65 protein and correlation in the experimental group of 60 cases of papillary carcinoma, 20 cases of follicular carcinoma，20 cases of medullary carcinoma，30 cases of healthy thyroid tissue as control group, 30 cases of thyroid adenoma thyroid adenoma，30 cases of nodular goiter patients with nodular goiter. Results NF-kB p50 protein in 100 cases of thyroid cancer positive rate 73.00%, showing high expression of the phenomenon, nodular goiter 30 cases of thyroid adenoma patients with thyroid adenoma and 30 cases of nodular goiter patients in the positive rate of tissue and 33.33% 30.00% respectively, showed low expression of the phenomenon. In 30 cases of healthy thyroid tissue positive rate 6.67%, showing a very low expression of the phenomenon. By X2 test, draw NF-kB p50 protein in thyroid cancer tissues was significantly lower than non-cancerous tissue, and the difference was statistically significant (P 0.05). NF-kB p65 protein in 100 cases of thyroid cancer positive rate 74.00%, the same phenomenon was highly expressed in 30 cases of nodular goiter patients with nodular goiter and 30 cases of thyroid adenoma thyroid gland the positive rate of tumor tissue was 36.67% and 40.00%, respectively, expression rate is relatively low. In 30 cases of healthy thyroid tissue positive rate 10.00%, the same as the phenomenon of very low expression. By X2 test, draw NF-kB p65 protein in thyroid cancer tissues was significantly lower than non-cancerous tissue, and the difference was statistically significant (P 0.05). NF-kB p50 protein in tumor diameter ≥1.0 cm group and tumor diameter 1.0 cm positive rate set at 79.41% and