Chapter16抗帕金森病药Antiparkin到sonismDrugs.pptVIP

Chapter 16抗帕金森病药Antiparkinsonism Drugs Muhammad Ali, the greatest boxer who suffers from parkinsonism, lit the Olympic flame at the 1996 Summer games in Atlanta ... Pakinson disease, 也称震颤麻痹 病变部位： 黑质 － 纹状体 (substantia nigra) (striatum) 病因：黑质－纹状体内多巴胺神经功能障碍 MPTP（1-甲基-4苯基-1，2，3，6四氢吡啶） PD四组征候群 ⑴ 静止性震颤 (resting tremor) ⑵ 肌肉僵直 (rigidity)：肌张力增强 运动困难、 面具脸 ⑶ 运动障碍(akinesia) ⑷ 姿势异常(postural dysfunction) Drugs treated on PD —左旋多巴 —卡比多巴 —溴隐亭，培高利特 —金刚烷