8电子传递与氧感化磷酸化.ppt

* * * * * * * * * * Factors affecting oxidation phosphorylation Inhibitors Regulation by ADP Thyroid hormone Mitchondrial DNA mutation Inhibitors Inhibitors of respiratory chain e.g.rotenone、piericidin A and amobarbital, antimycin A, dimercaptopropanol (BAL) Uncoupler e.g.dinitrophenol，DNP Inhibitors of oxidative phosphorylation inhibiting both electron transport and ADP phosphorylation. e.g. oligomycin 电子传递受可用底物量和ADP量的调控。既无可氧化的底物又无ADP时为状态Ⅰ，加入ADP后为状态Ⅱ（无可用的底物），加入底物后为状态Ⅲ，ADP用完后为状态Ⅳ，再加入ADP后为状态Ⅲ，氧耗尽后为状态Ⅴ。 Regulation by ADP Thyroid Hormone Na+-K+ A