包尚联ICMIP-2013全体会议的发言.pptx

Present and Future of Medical Imaging Physics;Basic disciplines of health protection;2013/10/16;4 Major Modalities;Essential Task;2013/10/16;2013/10/16;Two most important molecules;Gene Mutation;突变, 超量表达基因, 抗原;Other Molecules;Complexity huge number;New Tasks on Devices and Probes;Molecular Nuclear Medical Imaging;2001，first Inter. Conference in molecular imaging in Boston 2002, May, Nature: Vasilis Ntziachristos et al: Fluorescence molecular tomography resolves protease activity in vivo 2002, October Mr. Tang Xiaowei hold the Xiangshan Science Symposium in Hang Zhou, Title: Molecular medical imaging. End of 2002，Based imaging measurements (including optical imaging) of the dynamics of molecular and cellular events Visualization, Science: One of the top ten breakthroughs 2006, 973 subject on molecular iamging set up, Tian Jie, Bai Jing and Bao Shanglian 2011, continued ;Diagnosis in earlier stage, distinguish Benign and malignant tumors； Develop new drugs：Pharmacology, toxicity, and in vivo stability, including the probes Testing the dynamical analysis model Quantitative parameters in parameter imaging ; ; ;TAC:时间活度曲线;;PET 3D Dynamic Data clustering results by K-means and hierarchical clustering combined;;MRI fMRI;Condition is Ripe ;e.g. Quantitative DEC-MRI;TAC:时间活度曲线;DCE-MRI 药代分析评估化疗效果的研究;化疗前 Ktrans 三维分布;Typical output curves;Evaluation after Chemotherapy for G4;Overview;BREAST IMAGING REPORTING AND DATA SYSTEM: BI —RADS ;THE SHORTAGE OF CHARACTERISTIC KINETIC CURVE (CKC);Neoadjuvant chemotherapy for locally advanced breast cancer;TWO-COMPARTMENT REFERENCE REGION PHARMACOKINETIC ANALYSIS;TRADITIONAL QUANTITATIVE TWO-COMPARTMENT REFERENCE REGION PHARMACOKINETIC ANALYSIS;Our solution;results;3D Ktrans maps show the proliferation area in the periphery with the increased Ktrans value in this area.;For 3D Ve map, the malignant area (defined by the Ktrans map) still has increased values in the rim where tumor locates. In the center of the tumor, the Ve value is