10-9-2+lipid+后metabolism.pptVIP

The Differences Between fatty acid biosynthesis and breakdown Intermediates in synthesis are linked to -SH groups of acyl carrier proteins (as compared to -SH groups of CoA Synthesis in cytosol; breakdown in mitochondria Enzymes of synthesis are one polypeptide Biosynthesis uses NADPH/NADP+; breakdown uses NADH/NAD+ and FAD/FADH2 Features Cellular location-cytosol Primers-- acetyl-CoA Activated 2-C units - malonyl-CoA Decarboxylation of malonyl-CoA and reducing power of NADPH drive chain growth Chain grows to 16-carbons Other enzymes add double bonds and more Cs Challenge: Ac-Co