炎症反应发的双通道.pptVIP

SGA 2003-W-6701-SS MS* Slide 5 Corticosteroids can influence the regulation of numerous mediatorsof the inflammatory process, including cytokines (ILs 1–8, 11–13), tumor necrosis factor-alpha, granulocyte macrophage colony-stimulating factor, adhesion molecules (intracellular adhesion molecule-1, vascular-cell adhesion molecule-1), and inducible enzymes (nitrogen oxide synthase and cyclo-oxygenase [COX]-2).7 These drugs, however, may act unpredictably on many inflammatory processes. The effects of corticosteroids on leukotriene synthesis depend on the cell type and whether the drugs are admi