克感利咽颗粒联合奥司他韦治疗儿童流行性感冒疗效观察.PDF

·286 · 现代药物与临床 Drugs Clinic 第 33 卷 第 2 期 2018 年 2 月 克感利咽颗粒联合奥司他韦治疗儿童流行性感冒的疗效观察 黄晓燕，高健群 广州市妇女儿童医疗中心 儿科，广东 广州 510120 摘 要：目的 探讨克感利咽颗粒联合奥司他韦治疗儿童流行性感冒的临床疗效。方法 收集广州市妇女儿童医疗中心 2015 年 4 月—2017 年 5 月收治的流行性感冒患儿 112 例，随机分为对照组和治疗组，每组各 56 例。对照组患儿口服磷酸奥司他 韦胶囊，2 mg/kg ，2 次/d 。治疗组在对照组基础上口服克感利咽颗粒，1 袋/次，2 次/d 。两组患儿均连续治疗5 d 。观察两组 患者临床疗效，比较治疗前后两组患儿临床症候积分和症状缓解时间。结果 治疗后，对照组和治疗组临床总有效率分别为 92.86%和 100.00%，两组比较差异具有统计学意义（P ＜0.05 ）。治疗后，两组发热、鼻塞流涕、咳嗽咯痰、头痛、恶寒和全 身乏力积分均较治疗前明显降低，同组比较差异具有统计学意义（P ＜0.05 ）；且治疗组各临床症状积分均明显低于对照组， 同时治疗组鼻塞流涕、咳嗽咯痰、恶寒和全身乏力的缓解时间相比对照组明显缩短，两组比较差异具有统计学意义（P ＜0.05 ）。 结论 克感利咽颗粒联合奥司他韦治疗儿童流行性感冒可显著缩短临床症状缓解时间，提高临床治疗效果。 关键词：克感利咽颗粒；磷酸奥司他韦胶囊；流行性感冒；临床疗效；发热；鼻塞流涕 中图分类号：R985 文献标志码：A 文章编号：1674 - 5515(2018)02 - 0286 - 04 DOI: 10.7501/j.issn.1674-5515.2018.02.017 Clinical observation of Kegan Liyan Granules combined with oseltamivir in treatment of children with influenza HUANG Xiao-yan, GAO Jian-qun Department of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou 510120, China Abstract: Objective To study the curative effect of Kegan Liyan Granules combined with oseltamivir in treatment of children with influenza. Methods Children (112 cases) with influenza in Guangzhou Women and Children’s Medical Center from April 2015 to May 2017 were randomly divided into control and treatment groups, and each group had 56 cases. Children in the control group were po administered with Oseltamivir Phosphate Capsules, 2 mg/kg, twice daily. Children in the treatment group were po administered with Kegan Liyan Granules on the basis of the control group, 1 bag/time, twice daily. Children in two groups were treated for 5 d. After treatment, the clinical efficacy was evaluated, and the clinical symptoms scores and symptom alleviative time in two groups before and after treatment were compared. Results After trea