肉桂酸合成文献..doc

Supplementary information. Structure Activity Relationship of trans-Substituted-Propenoic Acid Derivatives on the Nicotinic Acid Receptor HCA2 (GPR109A). J.P.D. van Veldhoven, C.C. Blad, C.M. Artsen, C. Klopman, D.R. Wolfram, M.J. Abdelkadir, J.R. Lane, J. Brussee and A.P. IJzerman Division of Medicinal Chemistry, Leiden/Amsterdam Center for Drug Research, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands. 1. Chemistry. All reagents used were obtained from commercial sources and all solvents were of analytical grade. 1H and 13C NMR spectra were recorded on a Bruker AV 400 (1