从肿瘤微环境角度解析肿瘤免疫治疗的现状与未来-中国肿瘤生物治疗.PDFVIP

中国肿瘤生物治疗杂志 Chin J Cancer Biother, Jul. 2017, Vol. 24, No. 7 ·693 · DOI：：10.3872/j.issn.1007-385x.2017.07.001 ∙专家论坛∙ 从肿瘤微环境角度解析肿瘤免疫治疗的现状与未来 於宇，崔久嵬（吉林大学 第一医院 肿瘤中心，吉林 长春 130021） [摘 要] 以程序性死亡因子1（programmed death 1, PD-1）为代表的免疫检查点研究将肿瘤免疫治疗推向新的高度，其表明 操纵免疫负性调控途径可以创建有效的免疫治疗方法，同时也提示肿瘤微环境在抑制或增强免疫应答中发挥重要作用。因此， 剖析免疫应答与肿瘤微环境之间的相互作用机制，将有助于提供新的免疫治疗方案，并为个体化精准医疗奠定基础。本文 从肿瘤微环境如何影响免疫应答的角度，总结肿瘤免疫治疗的研究进展，以期为肿瘤免疫治疗提出新的治疗策略。 [关键词] 肿瘤微环境；肿瘤免疫治疗；免疫检查点 [中图分类号] R730.3;R730.51 [文献标识码] A [文章编号] 1007-385X （2017 ）07-0693-07 Analysis of present situation and future of cancer immunotherapy from the perspective of tumor microenvironment YU Yu, CUI Jiuwei （Cancer Center, the First Hospital of Jilin University, Changchun 130021, Jilin, China) [Abstract] The studies of immune checkpoint represented by programmed death 1(PD- 1) have pushed cancer im- munotherapy to a climax, which implies that modulating the negative immune regulatory pathway could create an ef- fective immunotherapy strategy. Meanwhile, the tumor microenvironment plays an important role in suppressing or enhancing immune response. Therefore, it will provide new immunotherapy strategy, and make foundation for indi- vidualized precision medicine, based on the mechanism of interation between immune response and tumor microen- vironment. This review summarized the research progress of cancer immunotherapy from the perspective of how the tumor microenvironment affects immune response, and aimed to propose a new strategy for cancer immunotherapy. [Key words] tumor microenvironment; cancer immunotherapy; immune checkpoint [Chin J Cancer Biother, 2017, 24(7): 693-699. DOI ：10.3872/j.issn. 1007-385X.2017.07.001] 崔久嵬 教授、主任医师、博士生导 肿瘤免疫治疗是通过激活机体免疫系统产生抗 师，现任吉林大学第一医院肿瘤中心 肿瘤作用的一种治疗方式。近年来以免疫检查点为