核仁素表达量增高与宫颈鳞癌和宫颈上皮内瘤变的病理分级正.PDFVIP

J South Med Univ, 2015, 35(10): 1511-1514 doi 10.3969/j.issn. 1673-4254.2015.10.29 ·1511 · 临床研究 参考文献：（应该未修改） 核仁素表达量增高与宫颈鳞癌和宫颈上皮内瘤变的病理分级正核仁素表达量增高与宫颈鳞癌和宫颈上皮内瘤变的病理分级正 相相关关 蒙国照，资 源，李红全，黄 铭，高 婷 湘南学院病理学教研室// 附属医院病理科，湖南 郴州 423000 摘要：目的 比较核仁素在宫颈鳞癌、宫颈上皮内瘤变和正常宫颈组织表达的差异，探讨核仁素表达增高在宫颈鳞癌发生发展中 的作用。方法 用免疫组化检测50 例宫颈鳞癌、65 例宫颈上皮内瘤变和正常宫颈组织中核仁素的表达，比较核仁素在3 种组织 中表达的差异，并分析核仁素表达水平与宫颈鳞癌和宫颈上皮内瘤变病理分级的关系。结果 宫颈鳞癌核仁素阳性表达率显著 高于宫颈上皮内瘤变和正常宫颈组织，宫颈上皮内瘤变核仁素阳性表达率显著高于正常宫颈组织，P0.01。Allred 免疫组化半 定量评分显示，核仁素表达量在宫颈鳞癌组织（7.6±0.3）显著高于宫颈上皮内瘤变（6.1±0.2）和正常宫颈组织（3.0±0.2），P0.01。 在宫颈上皮内瘤变显著高于正常宫颈组织，P0.01。核仁素表达量在中-低分化宫颈鳞癌（7.9±0.1）显著高于高分化鳞癌（7.0± 0.2），在高级别上皮内瘤变（6.0±0.1）显著高于低级别上皮内瘤变组织（4.0±0.2），P0.01。结论 宫颈鳞状上皮在癌变过程中核 仁素表达量增高，核仁素表达量增高与宫颈鳞癌和宫颈上皮内瘤变的病理分级呈正相关。 关键词：核仁素；CIN ；宫颈鳞癌 Nucleolin expression is correlated with carcinogenesis and progression of cervical squamous cell carcinoma MENG Guozhao, ZI Yuan, LI Hongquan, HUANG Ming, GAO Ting Department of Pathology, School of Basic Medicine and Affiliated Hospital of Xiangnan College, Chenzhou 423000, China Abstract: Objective To investigate the differential expressions of nucleolin in invasive cervical squamous cell carcinoma, cervical intraepithelial neoplasms (CIN) and normal cervical epithelial tissues and explore the role of nucleolin in the carcinogenesis and progression of cervical squamous cell carcinoma. Methods Fifty specimens of invasive cervical squamous cell carcinoma, 65 specimens of CIN, and 60 adjacent normal cervical epithelial tissue specimens were examined immunohistochemically for nucleolin expression. The correlation of nucleolin expression levels with histological grades of invasive cervical squamous cell carcinoma and CIN were analyzed. Results The specimens of invasive cervical squamous cell carcinoma showed a significantly higher po