人胰岛淀粉样多肽hiap时p单体及二聚体与popg磷脂膜相互作用的分子动力学模拟分析-凝聚态物理专业毕业论文.pdf.docxVIP

A B A B S T R A C T T he aggregatio n of h um an islet am y lo id po ly p eptide (h IA P P o r am y lin) is associated w ith the path o g enesis o f ty pe 2 d iabetes m e llitu s. In c reasin g ev idence su g gests th at th e in teractio n o f h IA P P w ith (3-ce ll m em b ran es p lay s a cru cial ro le in cytoto x icity. H ow ever, th e m o lecu lar m ech an ism o f interactio n and su b seq uent m em b ran e p erturbatio n at ato m ic lev e l rem ain s p o o rly u n d ersto o d . In th is stu d y, as a first step to u nd erstan d th e m echan ism o f h I