癌症相关成纤维细胞和胸腺嘧啶合成酶表达与结直肠癌耐药的分析.pdfVIP

中文摘要 5)。 没有相关性(r=O．055，P0．05)(Table 结论： 1 结直肠癌患者的性别、年龄、临床分期、组织学类型、有无淋巴结转 移、化疗后生存时间等均与间质内癌症相关成纤维细胞比例无关 2结直肠癌患者的性别、年龄、临床分期、组织学类型、有无淋巴结转 移化疗后生存时间等与癌组织TS阳性表达无关 3 结直肠癌组织间质内癌症相关成纤维细胞比例和TS表达两者问无相 关性 关键词：结直肠癌；平滑肌肌动蛋白；癌症相关成纤维细胞；胸苷酸 合成酶 英文摘要 The relevancebetweencancerassociatedfibroblasts putative ’·’ ● ¨ ‘ ·o ’ 。 o anatlle oI anacolorectalcancer exoresslonthyminesynthetase resistance drug ABSTRACT oneofthemostcommon Background：Colorectal and cancer(CRC)is mostserious worldwide．Inthewestern malignancies developedcountries， colorectalcancerrankedthesecond thecancer placeamong taketheforth datashowthatinour incidenceofcolorectalcancer country,the all ithasa toincrease of tumors，and place malignant tendency gradually． onthe and ofcolorectal However,researchassessment，treatment prognosis cancerisnot improvedsubstantially． evidenceshowsthatthe oftumoris Emerging development closely relatedwiththemicroenvironmentoftumorcells．Tumor iS of cellsandextracellular composedmesenchymal includes endothelial cel