LTP讲座讲义.pptVIP

LTP原理及其记录 华中科技大学同济医学院药理学系 华中科技大学创新研究院 杨远坚 华中科技大学同济医学院药理系陈建国教授实验室 陈建国教授：国家二级教授、“国家杰出青年基金”获得者，教育部“长江学者奖励计划”特聘教授，博士生导师，药理学系主任，校科技发展研究院常务副院长，武汉生物医药研究院常务副院长。 国家重点（培育）学科药理学、华中科技大学食品药品评价中心和教育部神经系统重大疾病重点实验室、武汉市新药创制国家综合性大平台等的主要组成单位之一。近些年在学习记忆、衰老及其调控、氧自由基和细胞保护、药物成瘾等方面取得了一系列进展。 代表性研究成果 Yang YJ, Wu PF, Long LH, Yu DF, Wu WN, Hu ZL, Fu H, Xie N, Jin Y, Ni L, Wang JZ, Wang F, Chen JG. Reversal of Aging-Associated Hippocampal Synaptic Plasticity Deficits by Reductants via Regulation of Thiol Redox and NMDA Receptor Function. Aging Cell. 2010 Jun 21. [Epub ahead of print] IF=7.55 Huang C, Hu ZL, Wu WN, Yu DF, Xiong QJ, Song JR, Shu Q, Fu H, Wang F, Chen JG. Existence and distinction of acid-evoked currents in rat astrocytes. Glia. 2010 Jun 14. [Epub ahead of print] IF=5.0 Liu J, Wang W, Wang F, Cai F, Hu ZL, Yang YJ, Chen J, Chen JG. Phosphatidylinositol-linked novel D(1) dopamine receptor facilitates long-term depression in rat hippocampal CA1 synapses. Neuropharmacology. May 21. 2009 Aug;57(2):164-71 IF=3.2 Mao LM, Wang W, Chu XP, Zhang GC, Liu XY, Yang YJ, Haines M, Papasian CJ, Fibuch EE, Buch S, Chen JG(联合通讯作者), and Wang JQ. Stability of NMDA receptors at the plasma membrane controls synaptic and behavioral adaptations to amphetamine, Nature Neuroscience, 2009,May;12(5):602-10 IF= 15.4 Wang T, Gu J, Wu PF, Wang F, Xiong Z, Yang YJ, Wu WN, Dong LD and Chen JG. Protection by Tetrahydroxystilbene glucoside against cerebral ischemia: Involvement of JNK, SIRT1, NF-κB pathways and inhibition of intracellular ROS/RNS generation. Free Radical Biology Medicine, 2009, Aug 1;47(3):229-40. IF=6.1 Ma LQ, Liu C, Wang ?F, Xie? N, Gu? J, Fu H, Wang JH, Cai ?F, Liu? J and Chen JG, Activation of phosphatidylinositol-linked novel D1 dopamine receptors inhibits high voltage activated Ca2+ currents in primary cultured striatal neurons. Journal of Neurophysiology, 101(5):2230-8. Zhang WT, Ruan JL, Wu PF, Jiang FC, Zhang LN, Fang W, Chen XL, Wang Y, Cao BS, Chen GY, Zhu YJ, Gu J, Ch