黄金胶囊对2型糖尿病大鼠胰岛素抵抗的影响.docVIP

PAGE PAGE 1 黄金胶囊对2型糖尿病大鼠胰岛素抵抗的影响 余臣祖1 安小平2 康学东2崔庆荣3 （1甘肃中医学院内科学教研室 甘肃 兰州 730000 2 甘肃中医学院附属医院内分泌科 甘肃 兰州 730000 3甘肃省中医药管理局 甘肃 兰州 730000） [摘要] 目的：探讨黄金胶囊对2型糖尿病(T2DM)大鼠胰岛素抵抗(IR)的影响，并初步探讨其作用机制。方法:采用给大鼠腹腔一次性注射小剂量链脲佐菌素（STZ），并加饲高热量饮食(富含脂肪和蔗糖)，制备T2DM伴IR大鼠模型，甘肃省中医药科研项目：项目编号：Gzk-2007-26。通讯作者：余臣祖，男，硕士研究生，讲师、主治医师，研究方向：中西医防治糖尿病，telE-mail： HYPERLINK http://www.dr-yu@ www.dr-yu@。观察黄金胶囊对糖尿病大鼠体重、血糖、血清TC、TG、HDL-C、血清胰岛素和胰岛素敏感性指数的影响。结果: 黄金胶囊能降低T2DM伴IR模型大鼠空腹血糖；黄金胶囊能降低病鼠血清TC、TG的水平，并提高HDL-C的水平，黄金胶囊能降低病鼠高胰岛素血症，提高了胰岛素敏感性指数；实验中未发现明显的不良反应。 甘肃省中医药科研项目：项目编号：Gzk-2007-26。 通讯作者：余臣祖，男，硕士研究生，讲师、主治医师，研究方向：中西医防治糖尿病，telE-mail： HYPERLINK http://www.dr-yu@ www.dr-yu@。 [关键词] 黄金胶囊;2型糖尿病;胰岛素抵抗;实验研究 Effects of huangjin capsule on insulin resistance in type 2 diabetic rats yu chenzu 1 an Xiaoping2 kang Xuedong2 cui qingrong 3 （1 gansu College of Tranditional Chinese Medicine Medicine teaching and research section gansu lanzhou 730000 2 Hospital Affiliated to gansu College of Tranditional Chinese Medicine Department of Endocrinology gansu lanzhou 730000 3 gansu Provincial Chinese Medicinec administration bureau gansu lanzhou 730000） [Abstract]　Objective：To investigate the effects of huang jin capsule on insulin resistance in type 2 diabetic rats and the primary pharmacological mechanism.Methods:The model of type 2 diabetic-insulin-resistant rats (T2DIRR) was made through intraperitonea injection of lower dosage of streptozocin(30mg·kg-1) and high caloric diet (abounded with sugar fat),the effects of huang jin capsule on weight,blood and serum contents of glucose, TC、TG、HDL-C、TNF-ａwere observed in the model rats.Results: huang jin capsule lowered significantly fasting blood glucose (FBG) and improved HDL-C; and reduced the TC、TG in T2DIRR. and reduced the concentration of insulin in hyperinsulinemia,and potentiated ISI (P0.01) in T2DIRR.Conclusion:In the experiment with type 2 diabetic-insulin-resistant rats，huang jin capsule can lower fasting blood glucose (FBG) and reduce le