Protein Production for StructueBased Drug Design基于结构的药物的设计的蛋白质的生产.pptVIP

Vertex: Building a Major Drug Company Focus:Small molecule drugs for major diseases Established: 1989; Public: 1991 Common stock: NASDAQ: VRTX 700 employees 3 sites Cambridge, US (headquarters) Oxford, UK San Diego, CA Traditional vs. Vertex Approach to Drug Discovery Therapeutic Area Perspective Single target approach Target Family Perspective Chemogenomics multi-target approach Expanding Parallel Drug Discovery into Gene Families Content Structural Genomics vs Structure Based Drug Design Much in common Expression strategy for higher output Parallel expression of E.coli insect cells Q