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High Blood Pressure Cardiovascular Prevention
/10.1007/s40292-018-0296-6
POSITION PAPER
Nutrients and Nutraceuticals for the Management of High Normal
Blood Pressure: An Evidence‑Based Consensus Document
1 2 3,4 5 1 2
Arrigo F. G. Cicero · Davide Grassi · Giuliano Tocci · Ferruccio Galletti · Claudio Borghi · Claudio Ferri
Received: 24 October 2018 / Accepted: 18 December 2018
© Italian Society of Hypertension 2019
Abstract
Essential hypertension still represents the most common cardiovascular risk factor, which is responsible for the vast major-
ity of global burden of disease, worldwide. Antihypertensive treatment aimed at lowering blood pressure (BP) levels to the
recommended therapeutic targets has demonstrated to reduce risk of developing major cardiovascular, cerebrovascular and
renal complications. Despite these evidence, overall rates of BP control are dramatically low in most European and Western
countries, as well as in the so called developing countries, thus contributing to the increasingly amount of hypertension-related
costs and disabilities. For these reasons, preventive strategies aimed at improving BP control rates in treated hypertensive
patients and reducing high-normal BP levels in asymptomatic otherwise healthy individuals may contribute to reduce the
burden of disease related to hypertension. In this view, an extensive use of nutrients and nutraceuticals has demonstrated
to provide favorable efects in hypertension management and control, beyond the adoption of pharmacological and non-
pharmacological interventions. These interventions can efectively and safely reduce BP levels to targets and prevent disease
progression form high-normal BP levels towards stage 1 hypertension. The present consensus document will systematically
describe and critically analyze the currently available
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