用不保护或少保护的糖基受体合成寡糖.pdf

15 4 化　学　进　展 Vol. 15 No. 4 2003 7 PROGRESS IN CHEMISTRY 　 July, 2003 用不保护或少保护的糖基受体合成寡糖* 孔繁祚 (中国科学院生态环境研究中心　北京 100085) 　　用不保护或少保护的葡萄糖、甘露糖、鼠李糖 为糖基受体,经由糖原酸酯的中间体,能高区选 和立体选地合成寡糖。 T-(→1 6) -连接的甘露寡糖、U-( →1 6)-连接的葡萄寡糖、 3,6-支化的甘露寡糖及葡萄 寡糖用此方法能用很简单步骤合成,如具有重要生物活性的寡糖植保素激活剂葡萄六糖、具有抗肿瘤活性的 香菇多糖的活性片段,以及 一些具有重要生理功能的多糖的重复单元等。本文同时简述了用少保护的半乳糖 和氨基葡萄糖为糖基受体合成寡糖的进展。 　寡糖合成　不保护的糖　受体 : 621. 3; 53　: 　: 1005-281 (2003)04-0295-24 O A X Synthesis of Oligosaccharides with Unprotected or Lightly Protected Glycosyl Acceptors Kong Fanzuo ( Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China) 　 - Abstract Regio and stereoselective synthesis of oligosaccharides with unprotected or lightly protect- ed gluco-, manno-and rhamnose as glycosyl acceptors was achieved via sugar orthoester formation-rear- rangement. T-( →1 6) -Linked mannose oligosaccharides, U-( →1 6) -linked glucose oligosaccahrides, and 3, 6-branched mannose and glucose oligosaccharides were conveniently synthesized with quite simplified pro- cedures. Biologically important oligosaccharides such as phytoalexin elicitor glucohexaose, antitumor frag- ments of lentinan, and some repeating units of biologically important polysaccharides were prepared readi- ly. Recent progress in regioselective synthesis of oligosaccharides with lightly protected glucosamine and galactose as acceptors was also outlined. Key words　oligosaccharide syntheses; unprotected sugars; glycosyl acceptors [7] , 。 、