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中 国 病 原 生 物 学 杂 志 20113 63
# 220 # J ournal of Pathogen B iology March 2011, Vol.6, No.3
# #
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冯梅, 王易* *
( , 201203)
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= R378.911 = A = 1673-5234(2011) 03-0220-03
[J our nal of Pathogen B iology . 2011 Mar; 6(3) : 220- 222.]
Current state of research on animal models of mycobacterium tuberculosis infection
FENG Mei, ANG Yi ( Dep ar tment of I mmunology and P athogen B iology , S hanghai Univ ersity of T CM ,
Shang H ai 201203, China
= Abstract My cobacterium tuber culosis (MTB) is amajor causeof human tuberculosis. A suitable animal model of MTB
infection must bepromptly established asa research tool sincethemechanismscausing tuberculosis andthe immune mech-
anisms involved in the bodys responseto MTB areunclear. Thispaper compares someof the problems common to differ-
ent rodent modelsof MTB infection already in use, which include animal strain selection, the route of infection, the infec-
tive dose, and evaluation criteria. These issues reveal the current state of research on animal models of MTB infection.
= Key words Tuberculosis; M y cobacter ium tuber culos is (MTB); animal model; review
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(M ycobacter ium tuber culosis , MTB) ,
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