中药热敷联合谷胱甘肽防治含顺铂化疗方案.PDFVIP

2015年05月第35卷第3期 现摇 代摇 中摇 医摇 药 May.2015摇 Vol.35 摇 No.3 ModernTraditional Chinese Medicine ·2摇摇摇7 · 中药热敷联合谷胱甘肽防治含顺铂化疗方案 * 所致周围神经毒性的临床观察 ** *** 沈永奇 摇 摇 冯献斌摇 摇 冯驭臣 摇 摇 宁雪坚摇 摇 斯韬摇 摇 石彧摇 摇 韦敏梅 (柳州市中医院,广西 柳州 545001) 摘摇 要:目的 评价中药热敷联合谷胱甘肽防止含顺铂方案化疗所致周围神经毒性的疗效和安全性。 方法 120例恶性肿瘤患者分为两组:治疗组(中药热敷联合谷胱甘肽预防周围神经毒性)60 例,对照组(未用特殊方 法预防周围神经毒性)60例。 结果 治疗组患者周围神经毒性的发生率明显低于对照组(P0.05),且治疗组患 者周围神经毒性持续的时间明显少于对照组(P0.05)。 结论 中药热敷联合钙镁合剂及谷胱甘肽防治含顺铂 方案化疗所致周围神经毒性疗效确切,且不良反应轻微。 关键词:中药热敷;谷胱甘肽;顺铂;周围神经毒性 中图分类号:R730.5摇 摇 文献标识码:B摇 摇 文章编号:1672-0571(2015)03-0027-03 DOI:10.13424/ ki.mtcm.2015.03.011 Clinical Observation on the Treatment of Peripheral Neurotoxicity Due to Cisplatin Chemotherapy by External Application of Chinese Herbs Combined Glutathione SHEN Yongqi,FENG Xianbin,FENG Yuchen,NING Xuejian,SI Tao,SHI Yu,WEI Minmei (The Liuzhou TCM Hospital,Liuzhou545001,China) Abstract摇 Objective: To evaluate the effect and safety of external application of Chinese herbs combined glutathi鄄 one in treating peripheral neurotoxicity induced by cisplatin chemotherapy. Methods: The 120 cases with malignant tumor weredividedinto60 casesoftreatmentandcontrolgroups. Thecombinationofexternalapplicationof Chineseherbs with glutathionewas usedtoprevent theperipheral neurotoxicity intreatment group,whileno special therapywasapplied in control group. Results:The incidenceof peripheral neurotoxicity inpatientsof treatment groupwas significantly lower than that of control group (P0.05) and its duration in treatment group was markedly shorter than that in control group (P0.05). Conclusion: Thecombinationofexternalapplicationof Chinese