胃癌肿瘤血管新生随细胞核内p53之累积而增加.PDFVIP

胃癌腫瘤血管新生隨細胞核內 p53之累積而增加 Tumor Angiogenesis Increases with Nuclear p53 Accumulation in Gastric Carcinoma 1 2 劉志銘 黃世貝 吳明賢 孫家棟 王秀伯 林肇堂 台大醫院內科部 病理部1 急診部2 Introduction Gastric carcinoma (GC): High prevalence and cancer-related death Gastric carcinogenesis: Cell cycle regulation, DNA repair, apoptosis, angiogenesis Genetic alterations: tumor supressor genes, oncogenes Tumor angiogenesis ↑: →advanced stage, non-curative resection, metastasis in GC