Article眼底OCT图像中糖尿病性黄斑水肿的分割Segmentationof.PDF

Opto-Electronic Engineering Article 光 电 工 程 2018 年，第45 卷，第7 期 DOI: 10.12086/oee.2018.170605 眼底 OCT 图像中糖尿病性黄斑 水肿的分割 * 何锦涛，陈明惠 ，贾文宇，秦显富，王 成，郑 刚 200093 摘要：糖尿病性黄斑水肿(DME)是导致成年人失明的主要原因之一，它的病理特征主要表现在视网膜内黄斑处液体的 积聚。由于光学相干层析成像(OCT)具有无创性、成像安全快速等特点，在临床上被广泛用于眼科疾病的诊断。本文 提出一种分割OCT 图像中糖尿病性黄斑水肿的方法，首先通过对图像的预处理，排除散斑噪声和血管对最终分割结果 的影响，再用改进的水平集方法有效地解决分割的问题，并计算水肿区域的面积，为后期的临床诊断治疗提供定性和 定量的工具，最后将本文方法在 15 个患有DME 成人的OCT 视网膜图像上进行验证。结果表明：囊状水肿分割的精 确度、灵敏度和Dice 相似性系数分别为81.12%、86.90%、80.05%。 关键词：糖尿病性黄斑水肿；光学相干层析成像；水平集；图像分割 中图分类号：R774.5；TP391.41 文献标志码：A 引用格式：何锦涛，陈明惠，贾文宇，等. 眼底OCT 图像中糖尿病性黄斑水肿的分割[J]. 光电工程，2018 ，45(7): 170605 Segmentation of diabetic macular edema in OCT retinal images * He Jintao, Chen Minghui , Jia Wenyu, Qin Xianfu, Wang Cheng, Zheng Gang Institute of Biomedical Optics Optometry, Shanghai Institute for Minimally Invasive Therapy, University of Shanghai for Science and Technology, Shanghai 200093, China Abstract: Diabetic macular edema (DME) is one of the important reasons leading to blindness. Its pathological features are mainly manifested in the accumulation of fluid in the retina. A method for segmentation of diabetic ma- cular edema in optical coherence tomography (OCT) retinal images is proposed. Firstly, through the image prepro- cessing, we exclude the impact of speckle noise and blood vessels on the final segmentation results. We used the improved level set method to solve the problem of segmentation effectively and calculated the area of edema area, which provides quantitative analytic tools for clinical diagnosis and therapy. Finally, we validated the method in this study on 15 OCT retina images with DME adults. The precision, sensitivity and dice similarity coeffici