爱通立疾病知识培训——脑卒中培训(瞬间溶栓-生机再现).ppt

* 由此我们看出，ECASS研究同样证实：患者在接受治疗后，神经功能改善明显，因此我们可以得出这样的结论：急性缺血性脑卒中发生6小时内应用爱通立溶栓治疗对改善患者的神经功能依然有利，溶栓治疗时间窗可以视情况拓宽到6小时。 * Both the international scientific society and the European health authorities would like to know whether thrombolysis initiated between 3 and 4.5 hours after stroke onset is effective and safe as suggested by a pooled analysis of the ATLANTIS, ECASS and NINDS rt-PA trials. Therefore ECASS III aims to evaluate efficacy and safety in the 3–4.5-hour time window.20 ECASS III is be a double-blind, randomised, placebo-controlled trial in the 3–4.5-hour time window with approximately 400 patients per study arm and the ECASS II dose of rt-PA.40–41 * Both the international scientific society and the European health authorities would like to know whether thrombolysis initiated between 3 and 4.5 hours after stroke onset is effective and safe as suggested by a pooled analysis of the ATLANTIS, ECASS and NINDS rt-PA trials. Therefore ECASS III aims to evaluate efficacy and safety in the 3–4.5-hour time window.20 ECASS III is be a double-blind, randomised, placebo-controlled trial in the 3–4.5-hour time window with approximately 400 patients per study arm and the ECASS II dose of rt-PA.40–41 * * A post-hoc adjusted ITT analysis (logistic regression) for the primary endpoint was undertaken for sensitivity purposes. This was conducted by including all baseline variables in the model and retaining those that were significant at P0.1. Thus treatment, baseline NIHSS, stroke onset to treatment time, smoking history and prior hypertension were retained. Treatment with rt-PA in this final prognostic model remains significant (P=0.037) with an OR of 1.42 and a 95% CI of (1.02 - 1.98). Age, prior stroke and diabetes were not prognostic at p0.1 and their inclusion inevitably introduces more variability; nevertheless, after also forcing these variables into the prognostic model, treatment with rt-PA remains significant (P=0.0495) with an OR of 1.40 and a 95% CI of (1.00 - 1