结肠清热丸治疗湿热内蕴型溃疡性结肠炎的临床研究-中医外科学专业论文.docxVIP

摘要 摘要 结肠清热丸治疗湿热内蕴型溃疡性结肠炎的临床研究 结肠清热丸治疗湿热内蕴型溃疡性结肠炎的临床研究 - - PAGE 13 - - - PAGE 10 - 摘 要 目的：本项研究旨在观察结肠清热丸对湿热内蕴型溃疡性结肠炎 （UC）的临 床疗效并探讨其机理。 方法：1、选取 UC 患者 60 例，均为河南省中医院门诊和住院病人，所有病例 均经结肠镜确诊，中医辨证为湿热内蕴型。按就诊顺序随机分为治疗组和对照组 各 30 例。两组患者在年龄、性别、病程、病情轻重程度及治疗前中医症状总积分 方面无明显差异，具有可比性（P＞0.05）。2、治疗组给予结肠清热丸治疗（10g/ 次，3 次/日，口服），对照组应用柳氮磺胺吡啶肠溶片（SASP）治疗（1.0g/次， 3 次/日，口服）。1 月为 1 个疗程，连续观察 2 个疗程。观察两组治疗前后症状及 体征、结肠镜下粘膜的变化情况。 结果：治疗后两组患者中医症状总积分比治疗前均有差异（ P＜0.05）；治疗 组中医症状 总积分的 改善明显优 于对照组 （ P＜0.05）。治疗组 临床 完全缓 解 15 例，有效 13 例，无效 2 例，总有效率 93.33%。对照组临床完全缓解 8 例，有效 12 例，无效 10 例，总有效率 66.67%。总有效率治疗组明显优于对照组（P＜0.05）。 治疗组能明显改善腹痛、腹泻、脓血便、里急后重等症状，其疗效优于对照组(P ＜0.05)。治疗后两组肠镜像较治疗前均有明显改善，两组治疗 前后肠镜下结肠粘 膜比较均有显著性差异(P＜0.05)；治疗组对肠镜粘膜像的改善明显优于对照组(P ＜0.05)。 结论：结肠清热丸具有清热解毒、消肿散结、活血止痛之功效，可明显改善 溃疡性结肠炎临床症状，使结肠粘膜炎症改变恢复正常，对溃疡性结肠炎有很好 的治疗效果。 关键词：结肠清热丸 溃疡性结肠炎 临床研究 Clinical Study of Jiechang Qingre Wan Treating Ulcerative colitis Of ShiReNeiYunXing Liu Xiaowen(Surgery of Traditional Chinese Medicine) Directed by Professor Xi Zuowu Abstract Object ： To observe the clinical effect of Jiechang Qingre Wan in treating ShiReNeiYunXing in ulcerative colitis（UC）. Methods:Select 60 UC patients who are the outpatients and inpatients from Henan Hospital of Traditional Chinese Medicine, all the patients have correct diagnosis through Colonoscopy. From dialectical point of view, the Chinese medicine practitioners consider it was ShiReNeiYunXing in ulcerative colitis. 60 UC patients were randomly divided into two groups, treatment group and control group; it was comparable between the two groups in age, gender, course of disease, illness , insignificant difference in the symptom total score before and after the treatment(P0.05).The treatment group were treated with Colon Heat-clearing pellets (Jiechang Qingre Wan), 10g, tid, po, the control group were treated with SASP, 1.0g, tid, po. One month is one treatment course, and all patients accepted two treatment courses. The changes of symptom, physical sign, and the mucous membrane under the Colonoscopy in t