解毒止痒法治疗慢性肾衰皮肤瘙痒（风湿毒瘀证）的临床观察-中西医结合临床肾病专业论文.docxVIP

万方数据 万方数据 中文摘要 目的：观察应用解毒止痒法治疗慢性肾衰皮肤瘙痒的临床疗效及临床安全 性，充分发挥中医药治疗慢性肾衰皮肤瘙痒的优势，并初步探讨其作用机制，为 以后进一步研究做好基础。 方法：选择符合入组受试标准的慢性肾功能衰竭皮肤瘙痒患者，随机分为对 照组、试验组进行观察。治疗方法：对照组为维持基础治疗，试验组除维持基础 治疗外加解毒止痒汤进行诊治。疗程设为 4 周。主要观察记录 2 组患者治疗前及 治疗后皮肤瘙痒程度、抓痕、皮肤干燥程度、和皮肤瘙痒对患者饮食、睡眠的影 响，以及肝肾功能、血常规、尿常规、24 小时尿蛋白定量、电解质、血脂以及 大便情况等方面的情况，通过统计分析进行综合性疗效评价和安全性评价。 结果：试验组共入组 14 例，痊愈为 0 例，显效为 2 例（14.29%），有效为 10 例（71.43%），无效为 2 例（14.29%），总有效率为 86.71%。对照组共入组 16 例，痊愈为 0 例，显效为 0 例，有效为 4 例（25.00%），无效为 12 例（75.00%）， 总有效率为 25.00%，组间比较，用卡方检验，P＜0.05，差异有统计学意义，试 验组优于对照组。两组于治疗前、治疗后进行了血常规、尿常规、肝肾功、电解 质、24 小时尿蛋白等检查，两组均未出现检查指标异常升高现象。治疗过程中、 治疗后，试验组与对照组均未出现不良情况。 结论：（1）解毒止痒法治疗慢性肾衰皮肤瘙痒（风湿瘀毒证）的方法有效， 可明显缓解患者的皮肤瘙痒症状。 （2）本研究提示解毒止痒法治疗慢性肾衰皮肤瘙痒（风湿瘀毒证）的 安全性可靠。 关键词：解毒止痒法；经验方；慢性肾功能衰竭皮肤瘙痒；临床研究。 ABSTRACT Objective: To observe the clinical effect and safety of toxin-eliminating and itch-relieving therapy in treating skin pruritus induced by chronic renal failure ( CRF skin pruritus) and to fully display advantages of Chinese medicine in its treatment through the exploration of the functional mechanisms for the further researches. Methods: The selected patients of CRF skin pruritus according with the test standards were randomized into control and treatment groups. Besides the initial treatment administered to the patients in control group, the cases in treatment group were given the Modified JieDu ZhiYang Decoction (the modified decoction of eliminating pathogenic factors and stopping itching), with 4 weeks course. The following factors of patients in two groups were observed and recorded before and after treatment, namely the extent of itching, scratch, skin dryness, pruritus impact upon patients’ diet and sleep as well as experimental results like hepatic and renal functions, blood and urine routine examinations, quantitative tests of 24h urinary protein, electrolytes, blood lipids and bowel movements. The evaluations of comprehensive clinical effects and safety were conducted through the systematic analysis of the obtained data. Results: In the