-氨基们苷类抗生素.pptVIP

氨基苷类和多粘菌素类; 氨基糖苷类抗生素是由氨基糖与氨基环醇通过氧桥连接而成的苷类抗生素。有来自链霉菌的链霉素等、来自小单孢菌的庆大霉素等天然氨基糖苷类，还有阿米卡星等半合成氨基糖苷类 。 ??Aminoglycosides contain amino sugars linked to an aminocyclitol ring by glycosidic bonds. They are polycations, and their polarity is in part responsible for pharmacokinetic properties shared by all members of the group.;虽然大多数抑制微生物蛋白质合成的抗生素为抑菌药，但氨基糖苷类抗生素却可起到杀菌作用，属静止期杀菌药。 Different from bacteriostatic agents, which are mostly effective by inhibition of microbial protein synthesis, the aminoglycosides are bactericidal. ;目的与要求;重点、难点;第一节 氨基苷类抗生素 aminoglycosides;一、抗菌作用与体内过程 ;门鉴拷