β内酰胺类抗菌药物不良反应分析研究.docVIP

个人收集整理 仅供参考学习 个人收集整理 仅供参考学习 PAGE / NUMPAGES 个人收集整理 仅供参考学习 282例β-内酰胺类抗菌药物地不良反应分析 潘海燕,凌春燕,朱青( 南京大学医学院附属鼓楼医院药剂科, 南京市210008) 摘要 目地:了解我院2009～2010年β-内酰胺类抗菌药物药品不良反应( ADR) 发生情况, 分析其影响因素, 以促进临床合理用药.方法: 以我院2009～2010年上报告国家药品不良反应监测中心地282例β-内酰胺类抗菌药物地ADR为考察对象,分别从患者年龄、性别、给药途径、使用药物种类以及临床表现等方面进行统计分析.结果: ADR涉及β-内酰胺类抗菌药物共33种, 以头孢曲松居首位, 其次为头孢呋辛和氨曲南; 以静脉途径给药引发地ADR最多; 282例ADR中, 大于60 岁地发生率最高, 占28.72%；临床表现以皮肤及其附件损害最常见.结论:β-内酰胺类抗菌药物发生ADR 与年龄、给药途径等多种因素相关, 应规范β-内酰胺类抗菌药物地临床应用, 避免或减少ADR地发生.b5E2RGbCAP 关键词:β-内酰胺类抗菌药物; 药品不良反应; 合理用药 Analysis for 282 Cases of Adverse Drug Reaction ofβ-lactamAntibioticsp1EanqFDPw Pan Haiyan , Ling Chunyan , Zhu Qing ( Dept.of Pharmacy, The Affiliated Drum Tower HospitalDXDiTa9E3d of Medical School of Nanjing University , Nanjing 210008)RTCrpUDGiT ABSTRACT Objective:To investigatethe reality and affecting factors of adverse drug reactions(ADR ) induced byβ-lactam antibiotics in our hospital during 2009~2010, in order to promote the proper use of drug inclinic.Methods :We classified and analyzed 282 cases of adverse drug reaction of β-lactam antibioticswhich is reported to National center for ADR Monitoring during 2009～2010, according tothe aspects of patients’ age and gender, administration route, species o f drugs and Clinicalmanifestations.Results: The ADR were caused by a total of 33 species ofβ-lactam antibiotics agents,among which Ceftriaxoneranked the first and was followed byCefuroxime and Aztreonam; The most causingroute was intravenous administration; of which, those patients’ aged above 60 years accounted for 28.72%;the damage of skin and its annex were themost common clinicalmanifestations.Conclusion: Multiplefactors contributed to the ADR, for example age and administration route. And the clinical application ofβ-lactam antibiotics of should be regulated toavoid or reduce the occurrence ofADR.5PCzVD7HxA KEYWORDS： β-lactamantibiotics; adverse drug reaction; rational administrationjLBHrnAILg β-内酰胺类抗生素系指化学结构中具有β-内酰胺环地一类抗生素,包括青霉素类、头孢菌素类、单环内酰胺类及其他非典型β-内酰胺类