不同给药方案对细菌性阴道病疗效的比较.docxVIP

不同给药方案对细菌性阴道病疗效的比较 王芳1张萍萍1尹利荣(通讯作者)1顾文玉2 (1天津医科大学第二医院妇科天津300211) (2天津市中心妇产科医院妇科天津300052) 【摘要】目的探讨不同的局部给药方案对细菌性阴道病的治疗效果。方法将 160例BV患者随机分成四组给予阴道局部用药,A组予甲硝哇400mgQdtimes;7d； B组予硝咲太尔250mgQdtimes;7d； C组予甲硝哇400mgQdtimes;7d后，予乳 杆菌250mgQdtimes;10d； D组予硝咲太尔250mgQdtimes;7d后，予乳杆菌 250mgQdtimes;10do分别于停药3天及停药2月后复查。结果 各组短期有效 率均高于75%, A、B、C三组有效率无明显差异；D组有效率明显高于其余三组， 差异有统计学意义。A组复发率则明显高于其余三组(Plt;0.05)o A组无明显阴 道微牛态环境改善作用；B、C组具有一定的阴道微生态环境改善作用，且作用 相近，两次复查差异不大。D组改善作用明显优于其余三组(Plt;0.05)o结论硝 咲太尔联合乳杆菌方案治疗BV,在有效率、复发率及阴道微牛态环境调整方面 均具有明显优势。单纯应用硝咲太尔作用与甲硝哇联合乳杆菌作用相近，亦有一 定的阴道微牛态环境改善作用，在有效率及复发率方面亦优于单用甲硝卩坐。单纯 应用甲硝哇，无明显阴道微牛态环境改善作用。 【关键词】细菌性阴道病 阴道微牛态平衡 乳酸杆菌 【中图分类号】R452 【文献标识码】A 【文章编号】2095-1752 (2014) 23-0061-03 Effect comparison of different therapeutic regimes in treating bacterial vaginosis Wang Fang Zhang pingping Yin Lirong (Department of Gynecology, The second hospital of Tianjin Medical University, Tianjin, 300211, China) Corresponding author : Gu Wenyu 【Abstract] Objective: To explore the effects of different local therapeutic regime ns in treati ng bacterial vagi no sis. Methods: 160 cases of BV patie nts were randomly divided into four groups received the partial vaginal medication treatment, group A was treated with metronidazole 400mgQdtimes;7d； group B was treated with Nifuratel 250mgQdtimes;7d: group C was treated with metronidazole 400mgQdtimes;7d first and then Lactobacillus 250mgQdtimes;10d； group D was treated with Nifuratel 250mgQdtimes;7d and then treated with Lactobacillus 250mgQdtimes;10d. We evaluated the curative effects after stopping treatment for 3 days and two mon ths. Result: The short-term effective rates of all groups were higher than 75%. The effective rate showed no d iff ere nces among groups A, B and C, however, D group had higher efficiency than the other three groups. The recurrenee rate of A group was sign讦icantly higher than the other three groups (Plt;0.05). The group A had no obvious vaginal micro ecological environment improvement effect, but group B and C had a c