褪黑素能类药物治疗睡眠障碍的研究进展.pdfVIP

　Pharm Care R es　20 10 Jun ;10(3) ·166 · , . · · 黄流清,赵忠新 [　]　, 、。, , 。(、/、) ,、、 。 [] 　;, ;/;; [] 　R 97 1.3　　　[]　A 　　　[]　167 1-2838 (2010)03-0166-05 Advance in research on treatment of sleep disorders with melatonergic drugs H UA N G Liuqing,Z HA O Zhong xin ＊(Depa r men of N eurology, Chang zheng Ho spi al, Second M ili a ry M edical U niver si y, Shanghai 20000 3, China) [ABSTRACT] 　Sleep diso rders is refrac o ry o mo s medica ions.T here is dema nds fo r he developmen of mo re eff ec ive, be - e r olerance a nd new er hy pno ic drug s.M ela o nin is a ho rmone sy n hesized principally in he pineal g land.I is cen rally in- v olved in main aining circadian rhy hmici y and reg ula ing sleep, media ed by mela onin recep o rs.I is of impor an sig nif i- cance o deve lop mela o ne rgic dr ug s and mela o nin recep o r ag onis s as drug s for rea ing sleep disorder s.In his rev iew , me- la onin, mela onin recep or ago nis s, such as ramel eo n, asimel eo n and ag omela ine, w hich a re curren ly being re searched in rea ing sleep diso rde rs are rev iew ed. [KEY WORDS]　mela onin;recep o r, mela onin;mela onin analog s and de riva ives;sleep ini ia io n and main enance disorder s; review [P ha rm Care Res, 2010, 10(3):166-170] 　　,、。 prachiasma ic nucleu s,SCN ),SCN 。, 、、, 、 [3] 。(mela onin ) 。( , 1 ～2 ), 、。 、, 、, , 。 [1] 　　。 。(、 /、) G , [1,2] SCN 、、、、、 , 。 、, 、、、 、、 　 。 cA