杀菌剂嘧菌酯的合成工艺_于福强.pdfVIP

Vol. 51, No. 11 AGROCHEMICALS Nov. 2012 1 2 1 2 2 2 2 2 (1. 110819 2. 110021) (E ) 2 [2 (6 4 ) ] 3 98.5% 1 98.0% TQ460.3 A 1006-0413(2012)11-0789-03 The Synthesis Techniques of Fungicide Azoxystrobin 1,2 1 2 2 2 2 2 YU Fu-qiang , NIU Dun , YU Chun-rui , WU En-ming , YE Yan-ming , XUE You-ren , WANG Zheng (1.Department of Chemistry School of Sciences, Northeastern University, Shenyang 110819, China; 2.State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Research Institute of Chemical Industry Co., Ltd., Shenyang 110021, China) AAbstract:bstract: [[Aims]Aims] The objective is to explore a new preparation method of azoxystrobin by the condensation reaction of material (E)-methyl 2-(2-(6-chloropyrimidin-4-yloxy)phenyl)-3-methoxyacrylate and 2-hydroxybenzonitrile, and the synthetic process was optimized and improved. [[Methods]Methods] In order to determinate the optimum parameters, the reaction conditions such as the kinds and the quantity of acid-binding agent, reaction temperature and the quantity of phase transfer catalyst were investigated, with toluene as solvent. [[Results]Results] Under the optimal reaction conditions, the synthetic yield was greater than 98.5%, refi ned by methanol once, product content was up to 98.0%. [[Conclusions]Conclusions]