课件：癌痛现代治疗的评述.ppt

* Tramadol for neuropathic pain James Hollingshead1, Rudolf Martin Dühmke2, David R Cornblath3 1Royal Sussex County Hospital, Brighton, UK. 2Cardiac Unit, Papworth Hospital, Cambridge, UK. 3Department of Neurology, Johns Hopkins Hospital, Baltimore, USA Contact address: JamesHollingshead, Royal Sussex CountyHospital, Eastern Road, Brighton, Sussex, BN2 5BE, UK. james@hollo.org. (Editorial group: Cochrane Neuromuscular Disease Group.) Cochrane Database of Systematic Reviews, Issue 1, 2009 (Status in this issue: Edited) Copyright ? 2009 The Cochrane Collaboration. Published by JohnWiley Sons, Ltd. DOI: 10.1002CD003726.pub3 This version first published online: 19 July 2006 in Issue 3, 2006. Re-published online with edits: 21 January 2009 in Issue 1, 2009. Last assessed as up-to-date: 13 March 2006. (Help document - Dates and Statuses explained) This record should be cited as: Hollingshead J, Dühmke RM, Cornblath DR. Tramadol for neuropathic pain. Cochrane Database of Systematic Reviews 2006, Issue 3. Art. No.: CD003726. DOI: 10.1002CD003726.pub3. Background Peripheral neuropathic pains often include symptoms such as burning or shooting sensations, abnormal sensitivity to normally painless stimuli, or an increased sensitivity to normally painful stimuli. Neuropathic pain is a common symptom in many diseases of the peripheral nervous system. Objectives We aimed to review systematically the evidence from randomised controlled trials for the efficacy of tramadol in treating neuropathic pain. Search strategy We searched the Cochrane Neuromuscular Disease Group Trials Register (June 2005), MEDLINE (January 1966 to June 2005), EMBASE (January 1980 to June 2005), and LILACS (January 1982 to June 2005) for randomised and quasi-randomised controlled trials. We also searched bibliographies of published trials. Selection criteria We included randomised and quasi-randomised controlled trials comparing tramadol with placebo, other pain relieving treatment, or no