Addenbrooke改良认知评估量表格在帕金森病患者认知障碍的价.docVIP

Addenbrooke改良认知评估量表在帕金森病患者认知障碍的价值初探基金项目： 基金项目：国家自然科学基金30700248)，科技部重大新药创制（2012Z002，2012ZX09303-003），江苏省神经退行性疾病重点实验室开放课题（SJ11KF05），江苏省卫生厅预防医学课题(YZ201022)，江苏省科技支撑计划（社会发展）项目(BE2011614)，江苏省六大人才高峰项目(WSN‐002)，南京市科技局国际联合研究项目? (201201106)，南京市医药科技发展项目(YKK10113)。 蔡荇 韦存胜 顾小花 程欣欣 张楚楚 王江波 孙琦 许利刚 徐俊 通讯作者 通讯作者：徐俊，Email: neurojun@126.com 南京医科大学附属脑科医院神经内科江苏省省级机关医院（江苏省老年医院）神经内科2100249。 摘要：目的 应用Addenbrooke改良认知评估量表(ACE-R)探讨帕金森病(PD)患者认知功能障碍情况。方法 对某三甲专科医院神经科门诊及住院治疗的24例PD患者行ACE-R评估。 结果 24例PD中11例MMSE异常与13例MMSE正常的患者比较，两组间在年龄方面差异有显著性(P0.05)，而病程、Hoehn-Yahr分期及UPDRS-motor差异无显著性；24例PD中14例ACE-R异常与10例ACE-R正常的患者比较，两组间年龄差异无显著性，而病程、Hoehn-Yahr分期及UPDRS-motor差异均有显著性(P0.05)。两组在ACE-R各分项中(注意和定向、记忆、语言流利性、语言及视空间)差异显著性明显(P0.005)。结论 ACE-R用作评估PD合并认知障碍敏感性高于MMSE，较MMSE更适合用于PD患者的认知障碍筛查。 关键词：帕金森病、认知障碍、痴呆、Addenbrooke改良认知评估量表 Preliminary study on application of the Addenbrookes Cognitive Examination-revised to assessment of cognition in Parkinson’s disease CAI Xing, WEI Cun-sheng, GU Xiao-hua, CHENG Xin-xin, ZHANG Chu-chu, WANG Jiang-bo, SUN Qi, XU Li-gang, XU Jun Department of Neurology, Nanjing BrainJIangsu Province Official Hospital, Nanjing 2100249, China Abstract：Objective To investigate the application of the Addenbrookes Cognitive Examination-revised(ACE-R) to the assessment of global cognition in Parkinson’s disease(PD). Methods Twenty-four PD patients were included. Their cognitive functions were assessed according to the ACE-R scales. Results Compared with 11 cases of abnormal MMSE scores and 13 cases of normal MMSE scores in 24 cases of PD patients, the age was significantly different in 2 groups with MMSE(P0.05),but the duration of symptoms, Hoehn-Yahr stage and UPDRS-motor were not significantly different. Compared with 14 cases of abnormal ACE-R scores and 10 cases of normal ACE-R scores in 24 cases of PD patients, the duration of symptoms, Hoehn-Yahr stage and UPDRS-motor were significantly different in 2 groups with ACE-R (P0.05),but the age was not significantly different. Th